Macleaya Cordata Extract, Sanguinarine, Chelerythrine

Specification

2%Total alkaloids  (1.5% Sanguinarine, 0.5% Chelerythrine) by HPLC

60% Total alkaloids (40% Sanguinarine, 20% Chelerythrine) by HPLC

70% Total alkaloids (50% Sanguinarine, 15% Chelerythrine) by HPLC

80% Total alkaloids (55% Sanguinarine, 20% Chelerythrine) by HPLC

90% Total alkaloids (60% Sanguinarine, 25% Chelerythrine) by HPLC

98% Sanguinarine chloride by HPLC
98% Chelerythrine chloride by HPLC

Introduction

Macleaya cordata, （also called as Pink Plumepoppy and Bocconia Cordata) a traditional Chinese medicine, is composed of a variety of active alkaloids such as sanguinarine and chelerythrine and is usually used as a natural additive in livestock because of its properties, including anti-microbial, anti-fungal, anti-inflammatory, and pesticidal activity.

Macleaya cordata extract is believed to be an effective natural appetiser in swine, bovine, poultry, and even fish nutrition. Macleaya cordata extract is blended from intact aerial parts and a fraction of quaternary benzo[c]phenanthridine alkaloids (QBAs), primarily sanguinarine and chelerythrine, and standardised to 1.5% w/w.

Sanguinarine (Sanguinarine chloride，CAS NO.5578-73-4,Formula: C20H14NO4.Cl) , a quaternary benzo phenanthridine alkaloid, is synthesized from dihydrosanguinarine, via the activities of dihydrobenzophenanthridine oxidase . It has been shown to have beneficial effects. It is antimicrobial, antifungal, adrenolytic, sympatholytic, immunomodulatory, and anti-inflammatory.

Chelerythrine  (Chelerythrine chloride, CAS NO. 3895-92-9, Mocular: C21H18NO4CL) is a quaternary benzo phenanthridine alkaloid. According to studies, it mostly exhibits tumour resistant, microbe resistant, and inflammation resistant qualities. Plus, the substance is a powerful disruptor when it comes to PKC (or protein kinase C). As such, the prospective utilization of Chelerythrine, as a form of inflammation resistance, has been the topic of much debate. Its qualities are linked to its capacity to engage with DNA and proteins. This is an enzyme that plays an important part in the control of signal transduction, cell propagation, and cell variation.

Application

1) Antibacterial, Antifungal, Antiprotozoan Property.

The Sanguinarine (pseudochelerythrine), chelerythrine, protopine as the main alkaloids (sulfate salt) extracted from Macleaya Cordata fruit clip have antibacterial, anti fungal, anti protozoan Property. So it has wild application in injection in Pharmacy, liniment in Cosmetics, also as anti plaque agent in toothpaste.

2) Insecticidal activity

The Sanguinarine and it's mainly isoquinoline alkaloids work together to trichomonas vaginalis and nematode, also killing larvicide. It is widely used in drugs for external use in Pharmacy and make Agricultural insecticide to do insect prevention and fungi-proofing before picking period of vegetable and fruits.

3) A world’s leading phytogenic feed ingredient and Veterinary Drug

It improves the feed intake, digestive performance and leads to a positive effect on amino acids balance and protein utilization, it is natural feed ingredient that can be delivered to all livestock, poultry, aquaculture without a withdrawal periods. Efficiency and increase appetite. Broad, nutritional and physiological gut level support during periods of stress, regardless of the cause. Dosage Common SPEC is 1.5% sanguinarine. 30-50g per Ton.

Certificate Of Analysis For Reference

Conclusion: Conform to specification.
Storage: Store in cool & dry place. Keep away from strong light and heat.
Shelf life:2 years when properly stored.

Conclusion Conform to specification.
Storage Store in cool & dry place. Keep away from strong light and heat.
Shelf life 2 years when properly stored.

Chromatogram For reference