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Macleaya Cordata Extract, Sanguinarine, Chelerythrine

Short Description:

  1. Synonyms: Pink Plumepoppy Extract
    Macleaya Cordata Seed Extract
    Macleaya Cordata Total alkaloids
    Bocconia Cordata Extract
    Sanguinarine
    Pseudo chelerythrine
  2. Appearance: Orange Brown Fine Powder, Bitter
  3. Active ingredients: Isoquinoline alkaloids: Sanguinarine (pseudochelerythrine), Chelerythrine, Protopine, α-Allocryptopine, β-Allocrytopine, Bocconine etc.

Product Detail

Product Tags

Specification

2%Total alkaloids  (1.5% Sanguinarine, 0.5% Chelerythrine) by HPLC

60% Total alkaloids (40% Sanguinarine, 20% Chelerythrine) by HPLC

70% Total alkaloids (50% Sanguinarine, 15% Chelerythrine) by HPLC

80% Total alkaloids (55% Sanguinarine, 20% Chelerythrine) by HPLC

90% Total alkaloids (60% Sanguinarine, 25% Chelerythrine) by HPLC

98% Sanguinarine chloride by HPLC
98% Chelerythrine chloride by HPLC

Introduction

Macleaya cordata, (also called as Pink Plumepoppy and Bocconia Cordata) a traditional Chinese medicine, is composed of a variety of active alkaloids such as sanguinarine and chelerythrine and is usually used as a natural additive in livestock because of its properties, including anti-microbial, anti-fungal, anti-inflammatory, and pesticidal activity.

Macleaya cordata extract is believed to be an effective natural appetiser in swine, bovine, poultry, and even fish nutrition. Macleaya cordata extract is blended from intact aerial parts and a fraction of quaternary benzo[c]phenanthridine alkaloids (QBAs), primarily sanguinarine and chelerythrine, and standardised to 1.5% w/w.

Sanguinarine (Sanguinarine chloride,CAS NO.5578-73-4,Formula: C20H14NO4.Cl) , a quaternary benzo phenanthridine alkaloid, is synthesized from dihydrosanguinarine, via the activities of dihydrobenzophenanthridine oxidase . It has been shown to have beneficial effects. It is antimicrobial, antifungal, adrenolytic, sympatholytic, immunomodulatory, and anti-inflammatory.

Chelerythrine  (Chelerythrine chloride, CAS NO. 3895-92-9, Mocular: C21H18NO4CL) is a quaternary benzo phenanthridine alkaloid. According to studies, it mostly exhibits tumour resistant, microbe resistant, and inflammation resistant qualities. Plus, the substance is a powerful disruptor when it comes to PKC (or protein kinase C). As such, the prospective utilization of Chelerythrine, as a form of inflammation resistance, has been the topic of much debate. Its qualities are linked to its capacity to engage with DNA and proteins. This is an enzyme that plays an important part in the control of signal transduction, cell propagation, and cell variation.

Application

1) Antibacterial, Antifungal, Antiprotozoan Property.

The Sanguinarine (pseudochelerythrine), chelerythrine, protopine as the main alkaloids (sulfate salt) extracted from Macleaya Cordata fruit clip have antibacterial, anti fungal, anti protozoan Property. So it has wild application in injection in Pharmacy, liniment in Cosmetics, also as anti plaque agent in toothpaste.

2) Insecticidal activity

The Sanguinarine and it's mainly isoquinoline alkaloids work together to trichomonas vaginalis and nematode, also killing larvicide. It is widely used in drugs for external use in Pharmacy and make Agricultural insecticide to do insect prevention and fungi-proofing before picking period of vegetable and fruits.

3) A world’s leading phytogenic feed ingredient and Veterinary Drug

It improves the feed intake, digestive performance and leads to a positive effect on amino acids balance and protein utilization, it is natural feed ingredient that can be delivered to all livestock, poultry, aquaculture without a withdrawal periods. Efficiency and increase appetite. Broad, nutritional and physiological gut level support during periods of stress, regardless of the cause. Dosage Common SPEC is 1.5% sanguinarine. 30-50g per Ton.

Certificate Of Analysis For Reference

Product Name: Macleaya Cordata Extract Latin Name: Macleayae Cordatae
Batch Number: 20210610 Used Part: Fruit
Batch Quantity: 50KG Analysis Date: June 11, 2021
Manufacture Date: June 10, 2021 Certificate Date: June 11, 2021
ITEM SPECIFICATION RESULTS
Description:
Appearance
Odor
Particle size
Extract Solvents
Orange brown fine Powder
Characteristic
95% pass 60 mesh sieve
Ethanol and Water
Conforms
Conforms
Conforms
Conforms
Assay:
Total Alkaloids
Sanguinarine
Chelerythrine
by HPLC
≥60.0%
≥40%
61.15%
45.36%
15.79%
Physical:
Solubility
Loss on Drying
Total Ash
Good solubility in water
≤6%
≤5%
Conforms
3.20%
0.60%
Chemical:
Arsenic (As)
Lead (Pb)
Cadmium (Cd)
Mercury (Hg)
Heavy Metals
≤2ppm
≤5ppm
≤1ppm
≤0.1ppm
≤10ppm
Conforms
Conforms
Conforms
Conforms
Conforms
Microbial:
Total Plate Count
Yeast & Mold
E.Coli
Salmonella
≤1000cfu/g Max
≤100cfu/g Max
Negative
Negative
Conforms
Conforms
Conforms
Conforms

Conclusion: Conform to specification.
Storage: Store in cool & dry place. Keep away from strong light and heat.
Shelf life:2 years when properly stored.

Product Name: Macleaya Cordata Extract Latin Name: Macleayae Cordatae
Batch Number: 20210121 Used Part: Fruit
Batch Quantity: 300KG Analysis Date: Jan. 21, 2021
Manufacture Date: Jan. 21, 2021 Certificate Date: Jan. 21, 2021

ITEM

SPECIFICATION

RESULTS

Description:
Appearance
Odor
Particle size
Carrier
Orange Red fine Powder
Characteristic
95% pass 60 mesh sieve
Maltodextrin

Conforms
Conforms
Conforms
Conforms

Assay:
Total Alkaloids
Sanguinarine
by HPLC
≥2.0%
≥1.5%

2.12%
1.52%

Physical:
Solubility
Loss on Drying
Total Ash
Good solubility in water
≤6%
≤5%

Conforms
5.80%
1.60%

Chemical:
Arsenic (As)
Lead (Pb)
Cadmium (Cd)
Mercury (Hg)
Heavy Metals
≤2ppm
≤5ppm
≤1ppm
≤0.1ppm
≤10ppm

Conforms
Conforms
Conforms
Conforms
Conforms

Microbial:Total Plate Count
Yeast & Mold
E.Coli
Salmonella
≤1000cfu/g Max
≤100cfu/g Max
Negative
Negative

Conforms
Conforms
Conforms
Conforms

Conclusion Conform to specification.
Storage Store in cool & dry place. Keep away from strong light and heat.
Shelf life 2 years when properly stored.

Chromatogram For reference

Chromatogram For Macleaya Cordata Extract 20210610 JL


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