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Milk Thistle Extract, Silymarin, Silybin

Short Description:

  1. Synonyms: Silybum Marianum Extract, Milk Thistle Seed Extract, Silybi Fructus Extract, Cardus marianus Extract, Silymarin
  2. Appearance: Orange Brown to White Fine Powder, Bitter
  3. Active ingredients: A Mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others.
    Silybin also known as silibinin (Silybinin A + Silybinin B), Isosilybinin A, Isosilybinin B,

Product Detail

Product Tags

Specification

70%-80% Silymarin

80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Actone USP

50% Silymarin + 30% Silybin extracted by Actone USP

60% Silymarin + 40% Silybin extracted by Actone

80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Ethyl Acetate USP

50% Silymarin + 30% Silybin extracted by Ethyl Acetate USP

55% Silymarin + 35% Silybin extracted by Ethyl Acetate

80%Silymarin, 45%HPLC (30% Silybin&Isosilybin) extracted by Ethanol USP

50% Silymarin + 30% Silybin extracted by Ethanol USP

55% Silymarin + 35% Silybin extracted by Ethanol

Water soluble 20%-40% Silymarin

80%-99% Silybin

Introduction

Milk Thistle, (also called as Silybum marianum(L.) Gaertn. or Carduus marianus L.), its seed contains a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others, Silibinin itself is a mixture of two diastereomers, silybin A and silybin B in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the fatty liver, non-alcoholic fatty liver, non-alcoholic steatohepatitis, the silymarin has the antioxidant, antiviral and anti-inflammatory properties

Milk Thistle Extract is extracted from the seed of the plant "Silybum marianum(L.) Gaertn. or Carduus marianus L." through different solvents as Actone, Ethyl Acetate and Ethanol.

Silybin (Silibinin, Silybinin, CAS NO.22888-70-6, Mocular:C25H22O10) a natural polyphenolic flavonoid, is a major bioactive component of silymarin isolated from the plant milk thistle (Silybum marianum) that has been extensively used in treating hepatic ailments in Asia and Europe.

Application

1) Liver Protecting
The silymarin have reproductive function of hepatocytes to stimulate the new cells form; and also produce protective film on hepatocytes to precaution of viral penetration to hepatocytes. It is used in medicine of live protection, such as tablet, capsule.

2) Excellent Antioxidant
It can clear free radical in human body, postpone senility.

3) Preventing Arteriosclerosi

4) A natural feed additive against hepatotoxic effects of feed aflatoxins
Function of silymarin in Feed protects against hepatotoxic effects of feed aflatoxins, Mycotoxins not only reduce animal performance, but they also cause significant liver damage. The seeds of the herb plant milk thistle contain a mixture of flavonolignans known as silymarin and can help in reducing liver damage when animals get in contact with mycotoxin contaminated feed.

Certificate Of Analysis For Reference

Product Name: Milk thistle Extract Latin Name: Silybum marianum (L.)Gaertn
Batch Number: 20200927 Used Part: Seed
Batch Quantity: 1000KG Analysis Date: Sept. 27, 2020
Manufacture Date: Sept. 27, 2020 Certificate Date: Sept. 30, 2020
ITEM SPECIFICATION RESULTS
Description:
Appearance
Odor
Particle size
Extract Solvents
Yellowish Brown Powder
Characteristic
100% pass 80 mesh sieve
Acetone and Hexane
Conforms
Conforms
Conforms
Conforms
Assay:
Silymarin
Silymarin calculated as Silybin (dry)
Silybins & Isosilybins
≥80% by UV
by HPLC
≥30% by HPLC
82.24%
49.54%
36.32%
Physical:
Loss on Drying
Sulphated Ash
≤5%
≤0.6%
2.83%
0.21%
Chemical:
Arsenic (As)
Lead (Pb)
Mercury (Hg)
Cadmium (Cd)
Heavy Metals
Solvent Residue
Hexane
Acetone
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤20ppm
≤290ppm
≤5000ppm
Conforms
Conforms
Conforms
Conforms
Conforms
Conforms
12ppm
3800ppm
Microbial:
Total Plate Count
Yeast & Mold
E.Coli
Salmonella
Staphylococcus
Aflatoxins
≤1000cfu/g Max
≤100cfu/g Max
Negative
Negative
Negative
≤20ppm
<10cfu/g
<10cfu/g
Conforms
Conforms
Conforms
Non Detective

Conclusion: Conform to specification of EP 6.0 and CP
Storage: Store in cool & dry place. Keep away from strong light and heat.
Shelf life: 2 years when properly stored.

Chromatogam For Reference

Milk Thistle Extract, Silymarin, Chromatogram


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