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Phellodendron Extract, Berberine, Berberine HCL

Short Description:

  1. Synonyms: Phellodendron Extract, Phellodendron chinense Extract, Phellodendron amurense Extract, Phellodendri Cortex Extract, Berberine HCL
  2. Appearance: Yellow Fine Powder, Bitter
  3. Active ingredients:Alkaloids (Berberine, Palmatine etc)

Product Detail

Product Tags

Specification

60% Berberine by HPLC
97%-98% Berberine HCL (Berberine Hydrocloride) as per CP2015
97%-98% Berberine sulfate by Titration

Introduction

Phellodendron Bark (Cortex Phellodendri) is one of the fifty fundamental herbs of traditional Chinese medicine. Known also as Cortex Phellodendri, it is the bark of one of two species of Phellodendron tree: Phellodendron amurense or Phellodendron chinense.

Phellodendron amurense also called as Amur cork tree is originated in North of China, and Phellodendron chinense produce in South of China, mainly in Sichuan Province.

Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids.

Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) is a yellow crystal powder, no odour, extremely bitter, it can be soluble in hot water, and slightly soluble in water or ethanol. According to the solvent used in production, it can be reacted into Berberine hydrochloride and Berberine sulfate

Application

The bark is categorized in a traditional Chinese medicine counterpart of humorism, affecting the kidney, urinary bladder and large intestine meridians.

Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) has A natural broad-spectrum antibiotic inhabits pathogenic microorganisms, such as bacteria, fungi, and protozoa, for the treatment of many diseases.

Berberine HCL (Berberine Hydrocloride CAS NO. 141433-60-5, Molecular: C20H18ClNO4) has antibacterial action on Gram-positive bacteria and Gram-negative bacteria, such as E. coli, pneumococcal, staphylococcus aureus, streptococcus, and salmonella typhi. Especially a strong antibacterial action on shigella dysenteriae, it also has some inhibitory effects on influenza virus, amoeba, leptospira and certain dermatophytes.

Berberine Sulfate (Berberine Sulphate, CAS NO. 6190-33-6, Molecular Formula:C40H42N2O15S) is usually used in  veterinary product, it has good water solubility.

Certificate Of Analysis For Reference

Product Name: Berberine HCL Botanical Name:
Batch Number: 20201108 Used Part:
Batch Quantity: 500KG Analysis Date: Nov. 8, 2020
Manufacture Date: Nov. 8, 2020 Certificate Date: Nov.12, 2020
ITEM SPECIFICATION RESULTS
Description:
Appearance
Odor
Taste
Particle size
Extract Solvent
Light Yellow crystalline Powder
Odorless
Extreme Bitter
100% pass 80 mesh sieve
Water & hydrochloric acid
Conforms
Conforms
Conforms
Conforms
Assay:
Berberine HCL
≥97% by Titration (CP2015) 98.02%
Physical:
Loss on Drying
Residue on ignition
≤12.0 %
≤0.2 %
10.80%
0.18%
Chemical: 
Heavy Metals
Arsenic (As)
Lead (Pb)
Mercury (Hg)
Cadmium (Cd)
Solvent Residue
Methanol
Ethanol
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤100ppm
≤500ppm
Conforms
0.184ppm
0.022ppm
0.006ppm
0.012ppm
2.18ppm
1.46ppm
Microbial:
Total Plate Count
Yeast & Mold
E. Coli
Salmonella spp
Staphylococcus aureus
Pseudomonas aeruginosa
≤1000cfu/g
≤100cfu/g
Absent
Absent
Absent
Absent
Conforms
Conforms
Conforms
Conforms
Conforms
Conforms

Conclusion: Conform to specification CP2015
Storage: Store in cool & dry place. Keep away from strong light and heat.
Shelf life: 24 months when properly stored.

Product Name: Berberine Sulphate Botanical Name:
Batch Number: 20200905 Used Part:
Batch Quantity: 75KG Analysis Date: Sept. 5, 2020
Manufacture Date:  Sept. 5, 2020 Certificate Date: Sept. 7, 2020
ITEM SPECIFICATION RESULTS
Description:
Appearance
Odor
Taste
Particle size
Extract Solvent
Light Yellow crystalline Powder
Odorless
Extreme Bitter
100% pass 80 mesh sieve
Water & hydrochloric acid
Conforms
Conforms
Conforms
Conforms
Conforms
Assay:
Berberine Sulphate
≥98% by Titration 98.03%
Physical:
Loss on Drying
Residue on ignition
≤15.0 %
≤0.2 %
14.02%
0.15%
Chemical:
Heavy Metals
Arsenic (As)
Lead (Pb)
Mercury (Hg)
Cadmium (Cd)
Chloride
≤10 ppm
≤2ppm
≤5ppm
≤0.1ppm
≤1ppm
≤40ppm
Conforms
Conforms
Conforms
Conforms
Conforms
Conforms
Microbial:
Total Plate Count
Yeast & Mold
E. Coli
Salmonella spp
Staphylococcus aureus
Pseudomonas aeruginosa
≤1000cfu/g
≤100cfu/g
Absent
Absent
Absent
Absent
Conforms
Conforms
Conforms
Conforms
Conforms
Conforms

Conclusion: Conform to specification CP2015
Storage: Store in cool & dry place. Keep away from strong light and heat.
Shelf life: 24 months when properly stored.

Berberine sulfate
Berberine HCL

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